INHIBITORY EFFECT OF SEROTONIN ON OVULATION IN ADULT RATS

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Abstract
SUMMARY: Serotonin (5HT, 100 mg/kg) given subcutaneously between 16.00 and 18.00 h on the day of pro-oestrus, at 17.00 h on day 2 of dioestrus and at 13.00 and 17.00 h on day 1 of dioestrus, inhibited ovulation in adult rats. It was ineffective at 13.00 h on the day of pro-oestrus and on day 2 of dioestrus. The anti-ovulatory effect at 17.00 h during pro-oestrus was reversed by pretreatment with 2–4 mg progesterone or 2·5 mg dipyridamole/kg. The effect at 17.00 h on day 2 of dioestrus was reversed by 2 μg oestradiol benzoate. Subcutaneous injection of 5HT antagonized the ovulatory action of exogenous luteinizing hormone and inhibited the passage of 22Na into ovary, uterus and muscle but not the pituitary. Intraventricular administration of 5HT (200 μg/rat) between 13.00 and 18.00 h during pro-oestrus had no effect on ovulation. These results suggest that subcutaneous administration of 5HT does not inhibit ovulation at a central site, but acts as a peripheral vasoconstrictor preventing the passage of hormones to their target organs.

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