Contribution of CD8+T Cells to Containment of Viral Replication and Emergence of Mutations inMamu-A*01-Restricted Epitopes in Simian Immunodeficiency Virus-Infected Rhesus Monkeys
- 1 June 2008
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 82 (11) , 5631-5635
- https://doi.org/10.1128/jvi.02749-07
Abstract
Here, we investigated the containment of virus replication in simian immunodeficiency virus (SIV) infection by CD8+lymphocytes. Escape mutations inMamu-A*01epitopes appeared first in SIV Tat TL8 and then in SIV Gag p11C. The appearance of escape mutations in SIV Gag p11C was coincident with compensatory changes outside of the epitope. Eliminating CD8+lymphocytes from rhesus monkeys during primary infection resulted in more rapid disease progression that was associated with preservation of canonical epitopes. These results confirm the importance of cytotoxic T cells in controlling viremia and the constraint on epitope sequences that require compensatory changes to go to fixation.Keywords
This publication has 16 references indexed in Scilit:
- First Glimpse of the Peptide Presentation by Rhesus Macaque MHC Class I: Crystal Structures of Mamu-A*01 Complexed with Two Immunogenic SIV Epitopes and Insights into CTL EscapeThe Journal of Immunology, 2007
- Compensatory Substitutions Restore Normal Core Assembly in Simian Immunodeficiency Virus Isolates with Gag Epitope Cytotoxic T-Lymphocyte Escape MutationsJournal of Virology, 2006
- Highly sensitive SIV plasma viral load assay: practical considerations, realistic performance expectations, and application to reverse engineering of vaccines for AIDSJournal of Medical Primatology, 2005
- Immunopathogenesis and immunotherapy in AIDS virus infectionsNature Medicine, 2003
- Viral Escape from Dominant Simian Immunodeficiency Virus Epitope-Specific Cytotoxic T Lymphocytes in DNA-Vaccinated Rhesus MonkeysJournal of Virology, 2003
- Viral evolution and challenges in the development of HIV vaccinesVaccine, 2002
- Dominance of CD8 Responses Specific for Epitopes Bound by a Single Major Histocompatibility Complex Class I Molecule during the Acute Phase of Viral InfectionJournal of Virology, 2002
- Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytesNature, 2002
- A Nonhuman Primate Model for the Selective Elimination of CD8+ Lymphocytes Using a Mouse-Human Chimeric Monoclonal AntibodyThe American Journal of Pathology, 1999
- Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 + LymphocytesScience, 1999