High Transfection Efficiency of Poly(4-vinylimidazole) as a New Gene Carrier
- 23 May 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Bioconjugate Chemistry
- Vol. 14 (4) , 707-708
- https://doi.org/10.1021/bc025611q
Abstract
Poly(4-vinylimidazole) (P4V) was obtained by free radical polymerization of 4-vinylimidazole (4V) prepared by decarboxylation of urocanic acid. P4V formed a complex with DNA that exhibited higher transfection effiency on Hela cells than polyethylenimine (PEI), through the proton sponge mechanism of the imidazole groups in the side chain of the P4V, and low cell toxicity.Keywords
This publication has 6 references indexed in Scilit:
- Development of Biomaterials for Gene TherapyMolecular Therapy, 2000
- Gene-Delivery Systems Using Cationic PolymersCritical Reviews in Therapeutic Drug Carrier Systems, 1999
- Antiangiogenic gene therapyProceedings of the National Academy of Sciences, 1998
- Peptide-Mediated Release of Folate-Targeted Liposome Contents from Endosomal Compartments1Journal of the American Chemical Society, 1996
- A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.Proceedings of the National Academy of Sciences, 1995
- Imidazole-containing Polymers. Synthesis and Polymerization of the Monomer 4(5)-VinylimidazoleJournal of the American Chemical Society, 1963