Renin release from filtering and nonfiltering kidneys stimulated by PGI2 and PGD2

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Abstract
Changes in renin secretion were studied during intrarenal infusion of PGI2 and PGD2 into filtering and into denervated nonfiltering kidneys of anesthetized unilaterally nephrectomized dogs. At 5 .times. 10-9 and 10-8 g .cntdot. kg-1 .cntdot. min-1, PGI2 significantly increased renin secretion from 136 .+-. 50 to 367 .+-. 167 and to 232 .+-. 62 ng .cntdot. h-1 .cntdot. min-1, respectively, in filtering kidneys and from 90 .+-. 28 to 328 .+-. 165 and to 295 .+-. 108 ng .cntdot. h-1 .cntdot. min-1, respectively, in nonfiltering kidneys without affecting mean arterial pressure. When blood pressure decreased in some dogs during infusion of 5 .times. 10-8 g .cntdot. kg-1 .cntdot. min-1 PGI2, renin secretion rose to 1280 .+-. 394 in filtering kidneys and to 855 .+-. 159 ng .cntdot. h-1 .cntdot. min-1 in nonfiltering kidneys. In filtering kidneys, 5 .times. 10-8 and 10-7 g .cntdot. kg .cntdot. min-1 PGD2 increased renin release from 177 .+-. 41 to 355 .+-. 47 and to 700 .+-. 149 ng .cntdot. h-1 .cntdot. min-1. PGD2 delivered at 10-8, 5 .times. 10-8 and 10-7 g .cntdot. kg-1 .cntdot. min-1 into nonfiltering kidneys stimulated renin secretion from 108 .+-. 38 to 176 .+-. 58, 271 .+-. 91, and 418 .+-. 150 ng .cntdot. h-1 .cntdot. min-1. Since both PGI2 and PGD2 significantly stimulated renin release from filtering and nonfiltering kidneys, these prostaglandins can modulate renin release via a direct stimulation of the juxtaglomerular cells or via mediation of the intrarenal baroreceptor mechanism.