Sigma B Contributes to PrfA-Mediated Virulence inListeria monocytogenes
Open Access
- 1 July 2002
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 70 (7) , 3948-3952
- https://doi.org/10.1128/iai.70.7.3948-3952.2002
Abstract
Transcription of the Listeria monocytogenes positive regulatory factor A protein (PrfA) is initiated from either of two promoters immediately upstream of prfA (prfAp1 and prfAp2) or from the upstream plcA promoter. We demonstrate that prfAp2 is a functional σB-dependent promoter and that a sigB deletion mutation affects the virulence phenotype of L. monocytogenes. Thus, the alternative sigma factor σB contributes to virulence in L. monocytogenes.This publication has 34 references indexed in Scilit:
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