Effect of Sterol Inhibitors on the Incorporation of14C-Isopentenyl Pyrophosphate into Artemisinin by a Cell-Free System fromArtemisia annuaTissue Cultures and Plants

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Abstract
A cell-free system from Artemisia annua L. shoot cultures and plants (shoots and roots) which is capable of incorporating 14 C-isopentenyl pyrophosphate (14 C-IPP) into artemisinin has been developed. The sterol inhibitors miconazole, AMO 1618, CCC, and MER 29 increased both the incorporation of 14 C-IPP into artemisinin by cell-free extracts and the production of artemisinin in shoot cultures of Artemisia annua.