Microbial Production of 3aα-H-4α-(3′-Propionic acid)-5α-hydroxy-7aβ-methylhexahydro-1-indanone-δ-lactone from Soybean Sterol
- 1 July 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Agricultural and Biological Chemistry
- Vol. 47 (7) , 1449-1454
- https://doi.org/10.1080/00021369.1983.10865815
Abstract
Fermentative production of 3aα-H-4α-(3′-propionic acid)-5α-hydroxy-7aβ-methylhexa-hydro-1-indanone-δ-lactone (HIL) from soybean sterol was studied in order to use it as an intermediate for chemical synthesis of 19-norsteroids. A mutant of Nocardia corallina converted 20 g/liter of soybean sterol into 2.8 g/liter of HIL with a 25% yield on a molar basis. The dominant factors improving the productivity were the use of an amino acid mixture as a nitrogen source and the preparation of the sterol suspension by sonication or with surface-active agents.This publication has 0 references indexed in Scilit: