Botulinum toxin type A for drooling in Parkinson's disease: A double-blind, randomized, placebo-controlled study
- 1 May 2006
- journal article
- clinical trial
- Published by Wiley in Movement Disorders
- Vol. 21 (5) , 704-707
- https://doi.org/10.1002/mds.20793
Abstract
To investigate the safety and efficacy of botulinum toxin type A (BoNTX) treatment to reduce sialorrhea in Parkinson's disease (PD), a double‐blind, randomized, placebo‐controlled study enrolled 32 PD patients complaining of excessive drooling. Patients received either 50 U Botox in each parotid gland or placebo without using ultrasound guidance. Subjects treated with BoNTX experienced a reduction in both drooling frequency and familial and social disability (Time × Group effect: P < 0.01), as well as in saliva production (Time × Group effect: P < 0.0001). No adverse events were recorded. BoNTX injections are safe and effective treatment for the management of PD‐related drooling. © 2006 Movement Disorder SocietyKeywords
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