Effects of 6-Mercaptopurine on Susceptibility of Guinea Pigs to Experimental Allergic Encephalomyelitis.
- 1 October 1962
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 111 (1) , 121-123
- https://doi.org/10.3181/00379727-111-27720
Abstract
Guinea pigs injected with both antigen (homologous brain plus Freund''s adjuvant) and 6-mercaptopurine (6-MP) showed a slightly higher incidence of urinary incontinence and rapid weight loss but no definite difference in incidence of paralysis than did animals given only antigen; no change in mean day of onset was evident. While antigen alone increased the number of circulating neutrophils (but not of lymphocytes), antigen and 6-MP together and 6-MP alone produced similar leukocyte patterns delayed but marked neutropenia, and a marked rapid decline in lymphocytes. In animals given both 6-MP and antigen, a left shift in the Arneth Index of neutrophils occurred, in spite of the reduced level of circulating neutrophils.Keywords
This publication has 1 reference indexed in Scilit:
- Prevention of Experimental Allergic Encephalomyelitis with 6-Mercaptopurine.Experimental Biology and Medicine, 1960