INTESTINAL VILLOUS ATROPHY IN CHRONIC ACTIVE HEPATITIS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 14  (8) , 1015-1018
Abstract
Of 16 patients with chronic active hepatitis (CAH), 3 had total or subtotal villous atrophy in a suction biopsy taken from the upper jejunum. One of the 3 patients had a history of intestinal dysfunction. The patients with abnormal intestinal mucosa had lower levels of serum albumin and higher levels of Ig[immunoglobulin]G than patients without intestinal mucosal changes. The occurrence of intestinal villous atrophy in CAH may be due to a genetically determined pre-disposition to CAH and celiac disease associated with HLA-B8, which was carried by all 3 patients. Trials with gluten-free diet in CAH associated with intestinal villous atrophy were initiated.

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