A First-Generation Whole Genome–Radiation Hybrid Map Spanning the Mouse Genome
Open Access
- 1 December 1997
- journal article
- Published by Cold Spring Harbor Laboratory in Genome Research
- Vol. 7 (12) , 1153-1161
- https://doi.org/10.1101/gr.7.12.1153
Abstract
We have assembled a first-generation anchor map of the mouse genome using a panel of 94 whole-genome–radiation hybrids (WG–RHs) and 271 sequence-tagged sites (STSs). This is the first genome-wide RH anchor map of a model organism. All of the STSs have been previously localized on the genetic map and are located 8.8 Mb apart on average. This mouse WG–RH panel, known as T31, has an average retention frequency of 27.6% and an estimated potential resolution of 145 kb, making it a powerful resource for efficient large-scale expressed sequence tag mapping.[All of the mapping data for the maps presented here have been deposited at the Research Genetics, Inc., web site and can be freely accessed and downloaded athttp://www.resgen.com/.]Keywords
This publication has 24 references indexed in Scilit:
- Whole genome radiation hybrid mappingTrends in Genetics, 1996
- Isolation and Characterization of a Mouse Homolog of the X-Linked Ocular Albinism (OA1) GeneGenomics, 1996
- Genomic Organization of the Mottled Gene, the Mouse Homologue of the Human Menkes Disease GeneGenomics, 1996
- Isolation and Chromosomal Mapping of a Mouse Homolog of the Batten Disease GeneCLN3Genomics, 1996
- Construction of a Mouse Whole-Genome Radiation Hybrid Panel and Application to MMU11Genomics, 1996
- A radiation hybrid map of the human genomeHuman Molecular Genetics, 1996
- A genetic map of the mouse with 4,006 simple sequence length polymorphismsNature Genetics, 1994
- Towards high resolution maps of the mouse and human genomes—a facility for ordering markers to 0.1 cM resolutionHuman Molecular Genetics, 1994
- Radiation hybrids: irradiation and fusion gene transferTrends in Genetics, 1993
- New method for mapping genes in human chromosomesNature, 1975