INVIVO P-31 NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY OF SUBCUTANEOUS 9L GLIOSARCOMA - EFFECTS OF TUMOR-GROWTH AND TREATMENT WITH 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA ON TUMOR BIOENERGETICS AND HISTOLOGY

  • 1 February 1988
    • journal article
    • research article
    • Vol. 48  (3) , 676-681
Abstract
In vivo 31P nuclear magnetic resonance spectroscopy was used to examine the bioenergetics of the rat 9L gliosarcoma during untreated growth and in response to chemotherapy with 1,3-bis(2-chloroethyl)-1-nitrosourea. Tumor growth was associated with a decline in the phosphocreatine and nucleoside triphosphate resonances, consistent with an increase in tumor hypoxia during untreated growth. Following chemotherapy with 1,3-bis(2-chloroethyl)-1-nitrosoura (10 mg/kg), tumor levels of phosphocreatine and nucleoside triphosphate rebounded while the level of inorganic phosphate in the tumor declined. Histological comparison of treated and untreated tumor sections 4 days posttreatment showed that the treated tumor had a lower proportion of necrotic cells, a higher proportion of viable cells, and a 5-fold higher level of interstitial space than the control tumor.

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