Outpatient parenteral treatment of bacterial infections: the Italian model as an international trend?

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Abstract
The choice of administration route for an antibiotic remains a fairly controversial matter, as confirmed by the variation in prescribing habits among different countries. This variation may result from difficulty in identifying standard criteria that would unequivocally indicate the necessity of oral or parenteral administration.1 In general, the decision to administer an antibiotic by the parenteral route is influenced by three main factors: (i) reduced gastrointestinal absorption in the patient; (ii) lack of appropriate oral antibiotics; and (iii) specific disease and related severity.

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