Prevention of Rotavirus-Induced Diarrhea in Neonatal Mice Born to Dams Immunized with Empty Capsids of Simian Rotavirus SA-II
- 1 March 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 149 (3) , 434-438
- https://doi.org/10.1093/infdis/149.3.434
Abstract
Female CF-l mice were immunized subcutaneously with a rotavirus vaccine consisting of noninfectious, purified empty capsids from simian rotavirus SA-11 and were given a booster dose at 14–17 days of gestation. The vaccinated animals developed high titers of rotavirus-specific IgG in colostrum and milk. Virus-specific IgA titers were significantly (150-fold) lower, and virus-specific IgM was not detected. These results contrast with those obtained in natural and experimental infections of the gastrointestinal tract with epizootic-diarrhea infant-mouse (EDIM) virus; in such cases, intestinal and lacteal virus-specific antibody is primarily of the IgA isotype. Suckling mice born to vaccinated dams were challenged with infectious EDIM virus and monitored for the development of diarrheal disease; these neonates acquired maternal antibody and did not develop diarrhea.Keywords
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