Increased Intracranial Pressure Caused by Increased Protein Content in the Cerebrospinal Fluid

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Abstract
THE thesis of this paper is that increased intracranial pressure and communicating hydrocephalus may result from any chronic process that significantly raises the level of the protein content of the cerebrospinal fluid. The increase in pressure is due to mechanical clogging, by the protein molecules, of the pores of the semipermeable membrane that constitutes the brain-blood barrier. That cellular and fibrinous exudate can obstruct these absorptive areas is well recognized. The possibility that objects the size of protein molecules can have the same effect has not previously been investigated. Interest in this subject was aroused by a case of ependymoma . . .

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