Progressive Poliodystrophy

Publisher Website
Google Scholar
Abstract
Case reports of degeneration of the cerebral gray matter are scarce in contrast to the numerous papers on disorders of white matter. According to Bullard,1the earliest account of cortical degeneration was that of Moore in 1879, but the first comprehensive pathologic study was by Alpers2in 1931. To date, approximately 40 cases of progressive poliodystrophy have been reported (see Blackwood et al3for recent review). These cases, mostly children, have in common the pathologic finding of degeneration of the gray matter, but clinically differ widely with regard to onset, symptoms, and course of disease, suggesting that the final state of degeneration of gray matter may have been derived in diverse ways. The pathologic findings also may differ to a lesser degree, resulting in a diverse terminology and differing views as to which cases should be placed in what niche. Synonyms for the disorder include Alper's disease,

This publication has 6 references indexed in Scilit: