Nitrogen Dioxide Inhibition of Viral-Induced Resistance in Alveolar Monocytes

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Abstract
Rabbit alveolar monocytes harvested from rabbits injected intratracheally with a 5 × 105 tissue culture infective dose (TCID00) of para-influenza-3 virus are resistant to an in vitro challenge with rabbit pox virus. However, if the rabbits are exposed to 25 ppm nitrogen dioxide (NO2) for three hours immediately after the para-influenza-3 virus inoculation or at 0, 3, 6, 12, or 24 hours before the inoculation of virus, the previously observed resistance does not develop. This refractory state lasts at least 96 hours in that the alveolar macrophages from animals exposed to NO2 are unable to produce interferon when inoculated with para-influenza-3 virus in vitro. Exposure to NO2 also appears to increase the adsorption rate of para-influenza-3 virus in the lungs of rabbits, but it does not inactivate or enhance the infectivity of the virus employed.

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