Reduced antioxidant status in obese children with multimetabolic syndrome

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Abstract
BACKGROUND: In our previous study, the negative correlation found between plasma insulin levels and plasma α-tocopherol concentrations suggested that decreased antioxidant vitamin levels and reduced antioxidant capacity might be a characteristic feature of obese children with multimetabolic syndrome (MMS). OBJECTIVE: To investigate lipid-soluble antioxidant vitamin levels and total antioxidant status (TAS) in obese children with and without MMS and in controls. SUBJECTS: In total, 16 control children (age: 16.2±1.1 y, BMI: 20.7±1.9 kg/m2, body fat (BF): 25.6±5.7%; mean±s.d.), 15 obese children (age: 13.4±2.1 y, BMI: 34.2±3.1 kg/m2, BF: 36.9±5.8%,) and 17 obese children without MMS (age: 14.4±2.3 y, BMI: 30.4±6.2 kg/m2, BF: 36.3±5.8%) were included in the study. METHODS: Body composition was determined by anthropometric methods. Vitamin analysis was carried out by high-performance liquid chromatography and TAS of the plasma was measured with commercially available kits. Plasma glucose, lipids and insulin were measured by standard laboratory methods. RESULTS: Plasma α-tocopherol and β-carotene levels corrected for plasma lipids (cholesterol + triglyceride) were significantly (PPβ-carotene supplementation.