Hepatocyte nuclear factor-4alpha mediates the stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1alpha (PGC-1alpha) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells
- 1 January 2003
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 369 (1) , 17-22
- https://doi.org/10.1042/bj20021382
Abstract
It has recently been shown that adenoviral-mediated expression of peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1 alpha) in hepatocytes stimulates glucose-6-phosphatase catalytic subunit (G6Pase) gene expression. A combination of fusion gene, gel retardation and chromatin immunoprecipitation assays revealed that, in H4IIE cells, PGC-1 alpha mediates this stimulation through an evolutionarily conserved region of the G6Pase promoter that binds hepatocyte nuclear factor-4 alpha.Keywords
This publication has 47 references indexed in Scilit:
- The Coactivator PGC-1 Is Involved in the Regulation of the Liver Carnitine Palmitoyltransferase I Gene Expression by cAMP in Combination with HNF4α and cAMP-response Element-binding Protein (CREB)Journal of Biological Chemistry, 2002
- The glucose-6-phosphatase systemBiochemical Journal, 2002
- Increase in class 2 aldehyde dehydrogenase expression by arachidonic acid in rat hepatoma cellsBiochemical Journal, 2001
- Differential Role of Hepatocyte Nuclear Factor-1 in the Regulation of Glucose-6-phosphatase Catalytic Subunit Gene Transcription by cAMP in Liver- and Kidney-derived Cell LinesJournal of Biological Chemistry, 2000
- Human Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 (PPARGC1) Gene: cDNA Sequence, Genomic Organization, Chromosomal Localization, and Tissue ExpressionGenomics, 1999
- Multiple Promoter Elements Are Required for the Stimulatory Effect of Insulin on Human Collagenase-1 Gene TranscriptionPublished by Elsevier ,1999
- Hepatocyte Nuclear Factor 1α Is an Accessory Factor Required for Activation of Glucose-6-Phosphatase Gene Transcription by GlucocorticoidsDNA and Cell Biology, 1998
- Analysis of Chromatin Structure byin VivoFormaldehyde Cross-LinkingMethods, 1997
- Cloning and sequencing of the 5′ region of the human glucose‐6‐phosphatase gene: transcriptional regulation by cAMP, insulin and glucocorticoids in H4IIE hepatoma cellsFEBS Letters, 1996
- Regulation of the expression of the phosphoenolpyruvate carboxykinase gene in cultured rat hepatocytes by glucagon and insulinEuropean Journal of Biochemistry, 1988