BINDING OF HEMATOPORPHYRIN DERIVATIVE TO HUMAN SERUM ALBUMIN
- 1 July 1984
- journal article
- research article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 40 (1) , 1-4
- https://doi.org/10.1111/j.1751-1097.1984.tb04545.x
Abstract
Dialysis of hematoporphyrin derivative fraction A (HpD‐A) off human serum albumin at 38°C followed the Hill equation for cooperative binding with saturation at 5 to 8. 600 dalton porphyrin units. Approximately 15% of the HpD‐A was free for concentrations typical of human serum in photoradiation therapy. Possible structures of the tumor‐localizing and ‐photosensitizing component in HpD‐A are considered. Of these, a folded‐over, covalent dimer appears to be more consistent with the photophvsical properties.Keywords
This publication has 12 references indexed in Scilit:
- HEMATOPORPHYRIN AS A PHOTOSENSITIZER OF TUMORS*Photochemistry and Photobiology, 1983
- PHOTODYNAMIC INACTIVATION OF R3230AC MAMMARY CARCINOMAIN VITROWITH HEMATOPORPHYRIN DERIVATIVE: EFFECTS OF DOSE, TIME, and SERUM ON UPTAKE and PHOTOTOXICITYPhotochemistry and Photobiology, 1983
- PHOTOSENSITIZED LYSIS OF LIPOSOMES BY HEMATOPORPHYRIN DERIVATIVEPhotochemistry and Photobiology, 1983
- HEMATOPORPHYRIN PHOTOSENSITIZATION OF SERUM ALBUMIN and SUBTILISIN BPN'Photochemistry and Photobiology, 1983
- Photoradiation Therapy — Clinical and Drug AdvancesPublished by Springer Nature ,1983
- INTERACTION OF HUMAN SERUM ALBUMIN WITH HEMATOPORPHYRIN AND ITS ZN2+‐AND FE3+‐DERIVATIVESInternational Journal of Peptide and Protein Research, 1981
- The interaction of human serum albumin and hemopexin with porphyrinsBiochimica et Biophysica Acta (BBA) - Protein Structure, 1980
- Equilibrium and kinetic studies of the aggregation of porphyrins in aqueous solutionBiochemical Journal, 1976
- Spectra of porphyrinsJournal of Molecular Spectroscopy, 1961