Hypoglycemic Activity of 3,5 Dimethylisoxazole

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Abstract
Summary 3, 5 dimethylisoxazole (U-21221) was found to be 188 times more potent orally than tolbutamide in glucose-primed fasted intact rats. U-21221 also increased glucose oxidation by intact rats. It did not lower blood sugar of eviscerate rats but was active in alloxan diabetic animals which were unresponsive to tolbutamide. It was suggested that the mechanism of action of 3,5 dimethylisoxazole was by stimulation of glucose oxidation by the gut and/or liver.

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