5-Fluorouracil in Management of Gorlin's Syndrome
- 20 April 1978
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 298 (16) , 913
- https://doi.org/10.1056/nejm197804202981613
Abstract
To the Editor: 5-Fluorouracil cream has been widely used in the treatment of selected skin cancers1 2 3 4 5 6 and especially in basal-cell carcinoma. Mansell et al.7 have demonstrated the phenomenon of "delayed hypersensitivity" after its application to premalignant and malignant areas of skin. Previously Ryan et al.,8 used 5-fluorouracil to define suitable donor areas and more recently advocated preoperative sensitization of malignant skin lesions.9 The histologic similarity to basal-cell carcinoma has led many patients with Gorlin's syndrome to be subjected to unnecessary radical treatment, either by operation or by the use of radiotherapy.10 A well documented review by Rayner et al. . . .Keywords
This publication has 5 references indexed in Scilit:
- BASAL CELL NEVUS SYNDROMEPlastic and Reconstructive Surgery, 1977
- What is Gorlin's syndrome? The diagnosis and management of the basal cell naevus syndrome, based on a study of thirty-seven patientsBritish Journal of Plastic Surgery, 1977
- THE USE OF 5-FLUOROURACIL CREAM TO DEFINE SUITABLE DONOR AREASPlastic and Reconstructive Surgery, 1970
- Topical Chemotherapy of Cutaneous Malignancy of the Head and NeckSouthern Medical Journal, 1969
- Selective Cytotoxic Effect of Topical 5-FluorouracilArchives of Dermatology, 1963