MERCURIAL DIURETICS: SOME HAZARDS OF MERCUHYDRIN; REPORT OF TWO CASES WITH ONE DEATH

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Abstract
Two patients receiving mercuhydrin (Na methoxyoximer-curipropylsuccinylurea with theophylline) intramusc. during treatment for congestive heart failure experienced severe reactions. One experienced severe pain in the eyes, head and lumbar region, nausea and vomiting, went into shock and died five hours after the intramuscular injn. of 2 cc. of mercuhydrin. Necropsy revealed marked nephrosis and perivascular infiltration of the blood vessels of the brain. The mechanism of death was unclear, possibly anaphylactic. Another patient experienced headache, nausea and vomiting, chills, fever, flushing, and coma following intramusc. admn. of 2 cc. of mercuhydrin. Intramusc. injn. of mercupurin (methoxyhydroxymercuripropylamide of trimethyl-cyclopentanedicarboxylic acid and theophylline) as well as aminophylline (containing theophylline) was well tolerated. Symptoms were reproducible by intramusc. injn. of 0.05 cc. of mercuhydrin.
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