THE HUMAN INTERLEUKIN-1-ALPHA-GENE IS LOCATED ON THE LONG ARM OF CHROMOSOME-2 AT BAND-Q13

  • 1 January 1989
    • journal article
    • research article
    • Vol. 73  (1) , 104-107
Abstract
Interleukin-1.alpha. (IL-1.alpha.) and interleukin-1.beta. (IL-1.beta.) are two biochemically distinct, but distantly related, polypeptidic cytokines that play a key role in inflammation, immunologic reactions, and tissue repair. Recently, it has been shown that IL-1.alpha. is identical to hematopoietin 1, which was described as a hematopoietic growth factor acting on early progenitor cells in synergy with other hematopoietic growth factors. In this report we discuss our use of in situ hybridization on human prometaphase cells with a human IL-1.alpha. cDNA probe to localize the human IL-1.alpha. gene on the proximal part of the long arm of chromosome 2 at band q13, in the same chromosomal region as the IL-1.beta. gene.

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