Leukotriene Modifier Use and Asthma Severity

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Abstract
The introduction of leukotriene modifiers, the first novel class of medications for the treatment of asthma in more than 2 decades,1 provides an opportunity to evaluate the clinical context in which patients receive new pharmacologic therapy for a chronic disease. Despite the recent emphasis on evidence-based medicine,2 it remains unclear how clinical trial evidence and practice guidelines are being translated into the actual treatments that patients receive.