A Case Report Including EM and DNA Repair Investigations in a Dermatosis Associated with Multiple Skin Cancers: Epidermodysplasia Verruciformis

Publisher Website
Google Scholar
Abstract
This report describes the clinical, histological and electron microscopic observations in a 51‐year‐old male with epidermodysplasia verruciformis (EV). Cells with early signs of malignant transformation were found closely connected with virus infected epidermal regions. Skin cancers appeared initially on sun‐exposed areas, such as the face and ear lobes. The UV‐induced DNA repair synthesis was therefore studied, utilizing peripheral leukocytes. The patient had 40% lower UV‐induced DNA repair synthesis than the mean of nine healthy subjects of the same age. These results suggest that a decrease in UV‐induced DNA repair synthesis in combination with a possibly oncogenic viral infection may enhance the disposition for somatic mutations and malignant transformation in patients with EV.