Effects of Chlorothiazide on the Pancreas

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Abstract
Since its introduction into clinical use in 1958 chlorothiazide has gained widespread acceptance as an effective diuretic and hypotensive agent. Because it is effective when taken by mouth, patients have found its use both convenient and economical. In addition, many patients report that by taking chlorothiazide daily as a diuretic they have become free of the "ups and downs" of intermittent mercurial therapy.With careful administration to avoid electrolyte depletion, the toxic effects of the drug have been rare. There have been scattered reports of chlorothiazideinduced papular skin rashes,1 exfoliative dermatitis,2 purpura3 and jaundice.4 In addition to such untoward reactions . . .