Unsymmetrically-substituted [2,2]metacyclophanes via a free-radical substitution reaction

Abstract
Substitution of [2,2]metacyclophane (1) with out transannular bonding has been performed using BzO·OBz–CuCl2–MeCN, to produce the 4-benzoate (3a) and the 8-cyanomethyl derivative (4).
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