SHORT CHAIN PEPTIDE INHIBITORS OF HUMAN RENIN
- 5 July 1985
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 14 (7) , 1041-1044
- https://doi.org/10.1246/cl.1985.1041
Abstract
The phenylalanine residue in the C-terminal sequence of angiotensin II was found to be important for the design of renin inhibitors. 1-Naphthyl-alanine(Nal(1))-containing tripeptide analogues such as benzyloxycarbonyl-Nal (1)-His-Leucinal (ES-188) and benzyloxycarbonyl-Nal(1)-His-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid (Statine) 2(S)-methylbuthylamid (ES-254) showed high potency and specificity to human renin.Keywords
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