Differential Responsiveness of A and G3H Mouse Mammary Tissues to Somatotropin-Containing Hormone Combinations.

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Abstract
Mammary tissues from A/Crgl and C3H/Crgl strains of mice were transplanted into mammary gland-free fat pads of female hybrids (C3H x A, A x C3H). These hosts were hypophysectomized-ovariectomized and treated with estradiol + progesterone + somatotropin for 21 days followed by cortisol + somatotropin for 5 days. Lobulo-alveolar growth from the C3H transplants was greater than that from the A transplants. Lactogenesis occurred in the majority of the C3H transplants, none of the A transplants, and occasionally in the mammary tissues of hybrid mice. It has been suggested that the differential responsiveness of A and C3H mammary tissues to somatotropin-containing hormone combination is due to the difference in the genetic make-up of the mammary tissues themselves. This genetic determinant can be transmitted by C3H to the hybrid offspring.