EFFECT OF SINGLE ORAL DOSE OF PHENOBARBITONE ON LYMPHOCYTE BLASTOGENIC RESPONSE IN MAN
Open Access
- 1 December 1980
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 52 (12) , 1205-1207
- https://doi.org/10.1093/bja/52.12.1205
Abstract
A single oral dose of phenobarbitone 1.5 mg kg−1 was given to 18 normal subjects to evaluate the effects on lymphocyte function. Serum barbiturate concentrations and lymphocyte blastogenic response to three mitogens (PHA, Con A, PWM) were tested before and at 2, 12 and 36 h after drug administration. A serum barbiturate plateau of about 2 ng ml−1 was maintained from 2 to 36 h. Lymphocyte blastogenesis was reduced with barbiturate compared with controls. However, the reduction was significant only at 36 h (P<0.01).Keywords
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