Adipose Tissue Regeneration in Adult Rats

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Abstract
Adipose tissue in subcutaneous, but not epididymal, depots of adult rats is restored following lipectomy. The restoration process proceeds in response to lipectomy alone but may be somewhat accelerated by a diet which normally promotes large increases in adipocyte number. That adult rats can both regenerate subcutaneous adipose tissue following lipectomy and increase adipocyte number when fed certain diets suggests that in at least some depots of the adult rat adipocyte precursor cells can proliferate and differentiate, and that some element of the proliferation/differentiation sequence is normally inhibited. Whether these same processes occur in man is unknown.