Serogrouping of Neisseria Gonorrhoeae

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Abstract
To assess the clinical correlation of serogroups of gonococci, isolates of gonococci from patients with disseminated and uncomplicated gonococcal infections in 3 cities [Seattle, Washington; Atlanta, Georgia; Denver, Colorado] in the USA were studied. Strains of N. gonorrhoeae belonging to serogroup WI represented 85 (84%) of 101 isolates from patients with disseminated gonococcal infection (DGI) and 68 (40%) of 168 isolates from patients with uncomplicated gonorrhea (P < 0.001). The auxotype Arginine-, Hypoxanthine-, Uracil- (AHU) represented 62 (61%) of 101 isolates from DGI and 54 (32%) of 168 isolates from uncomplicated infection (P < 0.001); all AHU isolates were serogroup WI. Among other auxotypes, WI strains represented 25 (64%) of 39 isolates from patients with DGI and 14 (12%) of 114 from uncomplicated infections (P < 0.001). In Atlanta only, 13 (34%) of 38 isolates from DGI were AHU, 31 (82%) were serogroup WI (P < 0.001). Thus, gonococci of serogroup WI are associated with DGI in these cities of the USA; this correlation appears to be independent of auxotype. Serogroup WI is correlated with serum resistance.

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