ACID AND PEPSIN SECRETION IN RESPONSE TO ENDOGENOUS AND EXOGENOUS CHOLINERGIC STIMULATION AND PENTAPEPTIDE

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Abstract
Summary: In conscious dogs with a simple gastric fistula, acid and pepsin outputs in response to endogenous (insulin, 2 deoxy D‐glucose) and exogenous (bethanechol chloride) cholinergic stimulation and in response to pentapeptide were compared. In response to insulin the highest 15 min. acid output was not significantly different, using doses varying from 0·1 U/kg. to 1·0 U/kg. but the 1 hr., 2 hr. and 4 hr. acid outputs increased with increased dose. Insulin (1·0 U/kg.). 2 deoxy D‐glucose (150 mg./kg.) and pentapeptide (8 μg./kg./hr.) were equal as stimulants of acid output. Maximal acid output in response to bethanechol was not obtained because of the severe side effects. Pepsin output in response to insulin, 2 deoxy D‐glucose and bethanechol paralleled acid output. Insulin. 2 deoxy D‐glucose and bethanechol were more powerful than pentapeptide as stimulants of pepsin output. Pepsin output in response to pentapeptide decreased with doses greater than 2·0 μg./kg./hr. even though acid output was still increasing.

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