Isolation, identification, and synthesis of rubesamide, a new naturally occurring cyclopropanecarboxamide from Fagara rubescens

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Abstract
Rubesamide [N-(3,4-methylenedioxyphenethyl)cyclopropanecarboxamide](1) has been isolated, together with chelerythrine and dihydrochelerythrine, from the light petroleum extract of the root bark of Fagara rubescens Planck ex Hook (f)(Rutaceae). Its identification and synthesis are reported.