COMPLEMENT (C-3) RECEPTORS ON DENDRITIC RETICULUM CELLS OF NORMAL AND MALIGNANT LYMPHOID-TISSUE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 48  (2) , 348-352
Abstract
This study investigated whether dendritic reticulum cells (DRC) in normal lymphoid tissue and in malignant non-Hodgkin''s lymphomas possess receptors for the 3rd complement components (C3 receptors). The in situ expression of C3 receptors in lymphoid tissue was studied by staining frozen tissue sections with an antiserum specific for human C3 receptors (AC3RS), using a modified immunoperoxidase method. DRC of normal and malignant lymphoid tissue apparently express large amounts of C3 receptors. Absorption experiments revealed that the C3 receptors of DRC are identical with, or at least share common antigenic sites with, the C3 receptors expressed by tonsil B cells.