Effect of diisopropyl 1,3-dithiol-2-ylidenemalonate (NKK-105) on fatty liver induced by carbon tetrachloride.
- 1 January 1981
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 31 (1) , 15-21
- https://doi.org/10.1254/jjp.31.15
Abstract
The therapeutic effect of diisopropyl 1,3-dithiol-2-ylidenemalonate (NKK-105) on the fatty liver induced by CCl4 was studied. The recovery from elevated liver triglyceride levels induced by CCl4 required over 20 days in 35 wk old rats, but 14 days in 6 wk old rats. This indicates that 35 wk old rats are useful for studying the therapeutic effect of NKK-105 on fatty liver. In rats with CCl4-induced fatty liver, NKK-105 lowered the hepatic triglyceride level, accelerated the rate of triglyceride release from the liver, enhanced the incorporation of 14C-leucine into microsomal protein, and increased the RNA content in microsomes. NKK-105 exerts a curative effect on CCl4-induced fatty liver by improving the impaired protein synthesis and by promoting lipoprotein secretion.This publication has 7 references indexed in Scilit:
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