Acute Viral Infection: Tissue Injury Mediated by Anti-Viral Antibody through a Complement Effector System
Open Access
- 1 November 1971
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 107 (5) , 1274-1280
- https://doi.org/10.4049/jimmunol.107.5.1274
Abstract
Anti-viral antibody was able to injure virus-infected cells in the presence of a complement effector system. In lymphocytic choriomeningitis (LCM) and mumps infected culture cells, viral antigen was present on the surface of cells and accessible to interact with anti-viral antibody. Once complement had been activated, cellular injury ensued with the amount of damage directly related to the proportion of cells containing viral antigen. Mice treated with cobra factor were protected from the lethal effects of LCM challenge while showing no deficiency in either infectious viral replication or presence and activity of sensitized lymphoid cells. Such mice showed significant depletion of C3 and total complement levels. Once cobra factor treatment was ended, protection disappeared rapidly, and C3 and total complement levels returned to normal.This publication has 0 references indexed in Scilit: