Combretastatin-A4 disrupts neovascular development in non-neoplastic tissue
Open Access
- 15 March 2001
- journal article
- Published by Springer Nature in British Journal of Cancer
- Vol. 84 (6) , 832-835
- https://doi.org/10.1054/bjoc.2000.1653
Abstract
Combretastatin-A4 phosphate (cis -CA-4) is a tubulin-binding agent currently undergoing clinical trials as an anti-tumour drug. We have investigated whether CA-4 functions as a tumour-specific anti-vascular agent using the hyperplastic thyroid as a novel in vivo model of neovascularization. CA-4 elicited pathological changes in normal tissue, manifested as the induction of multiple, discrete intravascular thrombi. These vascular-damaging effects indicate that CA-4P does not function as a tumour-specific agent but targets neovasculature irrespective of the primary angiogenic stimulus. © 2001 Cancer Research CampaignKeywords
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