A general synthesis of 1,7-disubstituted 1,4,7,10-tetraazacyclododecanes

Abstract
1,4,7,10-Tetraazacyclododecane reacts regioselectively in acid solution with several chloroformates to give 1,7-diprotected derivatives which could be alkylated and deprotected to afford 1,7-disubstituted 1,4,7,10-tetraazacyclododecanes.

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