Chemical-shift-selective filter for the in vivo detection ofJ-coupled metabolites at 3T

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Abstract
A chemical‐shift‐selective filter (CSSF) was applied to the detection of J‐coupled metabolites in the human brain. This filter is an acquisition‐based technique that requires the chemical shifts (CS's) of different metabolites, but not their whole multiplet structures, to be resolved. The sequence is based on the 2D constant‐time spin‐echo experiment, which yields pure CS spectra in the indirect dimension. Localization is achieved through point‐resolved spectroscopy (PRESS). The method enables unequivocal detection of glutamate and myo‐inositol, both in vitro and in vivo in the human brain, at 3T. Magn Reson Med 53:275–281, 2005.