A Technique for Assay of Goitrogens in Feed
- 31 October 1960
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Animal Science
- Vol. 19 (4) , 1181-1185
- https://doi.org/10.2527/jas1960.1941181x
Abstract
An assay procedure has been described which can be used to detect minute amounts (0.5–2 ppm.) of residues in tissues of goitrogen-fed animals. The technique described in rats consists in determining 24-hour I131 uptake after feeding the goitrogen (or tissues) for a period of 4 days and then comparing it with control I131 uptakes. A low-iodine diet, by enhancing I131 uptake, increased the sensitivity of the assay technique. By this method, tapazole at 0.00005−0.0002% (½–2 ppm.) and carbimazole at 0.0001−0.001% (1–10 ppm.) in low iodine feed could be detected as shown by reduced I131 uptake in comparison with controls. Copyright © . .This publication has 0 references indexed in Scilit: