14-3-3 proteins and growth control
- 1 January 2000
- book chapter
- Published by Springer Nature
- Vol. 4, 49-60
- https://doi.org/10.1007/978-1-4615-4253-7_5
Abstract
The 14-3-3 proteins constitute a family that is highly conserved in a wide range of organisms, including higher eukaryotes, invertebrates and plants. Variants of 14-3-3 proteins assembled in homo- and heterodimers were found to interact with diverse cellular proteins. Until recently, the biological role of 14-3-3 members was still poorly understood. However, the results of an increasing number of studies on their structure and function are converging to define 14-3-3 proteins as a novel type of adaptor that modulates interactions between components involved in signal transduction pathway and in cell cycle control.Keywords
This publication has 100 references indexed in Scilit:
- Isoforms of 14‐3‐3 protein can form homo‐ and heterodimers in vivo and in vitro: implications for function as adapter proteinsPublished by Wiley ,2000
- Association of the TLX-2 Homeodomain and 14-3-3η Signaling ProteinsJournal of Biological Chemistry, 1998
- 14-3-3 Proteins Interact with Specific MEK KinasesPublished by Elsevier ,1998
- 14-3-3β Protein Associates with Insulin Receptor Substrate 1 and Decreases Insulin-stimulated Phosphatidylinositol 3′-Kinase Activity in 3T3L1 AdipocytesPublished by Elsevier ,1998
- Activity and Autophosphorylation of LAMMER Protein KinasesJournal of Biological Chemistry, 1996
- The inhibitor protein of phosphorylated nitrate reductase from spinach (Spinacia oleracea) leaves is a 14‐3‐3 proteinFEBS Letters, 1996
- Effect of Mutations at Serines 1280–1283 on the Mitogenic and Transforming Activities of the Insulin-like Growth Factor I ReceptorPublished by Elsevier ,1996
- Post-translationally modified 14-3-3 isoforms and inhibition of protein kinase CMolecular and Cellular Biochemistry, 1995
- 14-3-3 Proteins: Hot numbers in signal transductionCurrent Biology, 1995
- Molecular Cloning and Expression of the Transformation Sensitive Epithelial Marker StratifinJournal of Molecular Biology, 1993