Cefepime is efficacious against penicillin- and quinolone-resistant pneumococci in experimental meningitis
Open Access
- 1 February 2002
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 49 (2) , 327-330
- https://doi.org/10.1093/jac/49.2.327
Abstract
In experimental rabbit meningitis, cefepime given at a dose of 100 mg/kg was associated with concentrations in the cerebrospinal fluid of between 5.3 and 10 mg/L and a bactericidal activity of −0.61 ± 0.24 δlog10 cfu/mL•h, similar to the standard regimen of ceftriaxone combined with vancomycin (−0.58 ± 0.14 δlog10 cfu/mL•h) in the treatment of meningitis due to a penicillin- and quinolone-resistant pneumococcal mutant strain (MIC 4 mg/L). Compared with the penicillin-resistant parental strain, the penicillin- and quinolone-resistant mutant was killed more slowly by cefepime and ceftriaxone in time-killing assays in vitro over 8 h.Keywords
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