Combined activity of metronidazole and gentamicin onBacteroidesfragilis in vivo andin vitro
- 1 January 1985
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 15 (1) , 77-82
- https://doi.org/10.1093/jac/15.1.77
Abstract
A mixed aerobic/anaerobic infection in mice was established by co-injecting Bacteroides ragilis and Escherichia coli into a thigh muscle. Metronidazole administration 6 h after this inoculation resulted in a dose-dependent decrease of Bact. fragilis at 18 h after drug administration. Co-administration of gentamicin with metronidazole resulted in a significant decrease of the numbers of E. coli but did not markedly nfluence the effect of metronidazole on Bact. fragilis.Keywords
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