Clinical Analysis on Steroids. XIV. Preparation of 2-Hydroxyestradiol 17β-Conjugates
Open Access
- 1 January 1980
- journal article
- research article
- Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI
- Vol. 100 (8) , 867-870
- https://doi.org/10.1248/yakushi1947.100.8_867
Abstract
To investigate the 17.beta.-substituent effect upon enzymatic O-methylation of catechol estrogen, substrates, e.g., 2-hydroxyestradiol 17.beta.-sulfate and the corresponding glucuronide, were prepared. The former was obtained by catalytic reduction of potassium 2,3-dibenzyloxyestra-1,3,5(10)-trien-17.beta.-yl sulfate. The latter conjugate was prepared by alkaline hydrolysis of methyl-[2,3-dibenzyloxyestra-1,3,5(10)-trien-17.beta.-yl-2,3,4-tri-O-acetyl-.beta.-D-glucopyranosid]uronate, followed by catalytic reduction.Keywords
This publication has 5 references indexed in Scilit:
- Enzyme-linked immunoassay of ursodeoxycholic acid in serum.Journal of Lipid Research, 1979
- Extraction of steroid conjugates with a neutral resinSteroids, 1968
- Biogenese von 2-Hydroxy-östrogen-3-methyläthern in vitroHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1966
- Hydrolysis of Ketosteroid Hydrogen Sulfates by Solvolysis ProceduresJournal of Biological Chemistry, 1958
- 2-METHOXYESTRONE, A NEW METABOLITE OF ESTRADIOL-BETA IN MAN1957