Comparison of tamoxifen and hypophysectomy in breast cancer treatment
- 15 March 1980
- Vol. 45 (6) , 1322-1325
- https://doi.org/10.1002/1097-0142(19800315)45:6<1322::aid-cncr2820450609>3.0.co;2-k
Abstract
The effectiveness of hypophysectomy and tamoxifen in treating advanced breast cancer was compared in a randomized study of 26 patients who had responded to prior oophorectomy or additive hormonal therapy. When patients failed to respond or relapsed from tamoxifen or hypophysectomy, the therapy was crossed over. In this designed sequence, the rate and duration of response observed with tamoxifen or hypophysectomy used as the first regimen were comparable. The results suggest that tamoxifen is effective in the posthypophysectomy phase and the sequence of hypophysectomy followed by tamoxifen in hormone-dependent breast cancer is preferable to achieve a maximal control of the disease.This publication has 6 references indexed in Scilit:
- Tamoxifen in advanced breast cancerCancer Treatment Reviews, 1978
- Hormonal Therapy of Breast Cancer: New Approaches and ConceptsAnnals of Internal Medicine, 1978
- Tamoxifen (Antiestrogen) Therapy in Advanced Breast CancerAnnals of Internal Medicine, 1977
- Plasma hormones in patients with advanced breast cancer treated with tamoxifenPublished by Elsevier ,1976
- Hypophysectomy in Metastatic Breast CancerArchives of Surgery, 1975
- Hypophysectomy in advanced breast cancerThe American Journal of Surgery, 1965