Comparative in vitro activity of RO 23-6240 (Fleroxacin), a new 4-quinolone derivative
- 1 August 1987
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Microbiology & Infectious Diseases
- Vol. 6 (4) , 482-485
- https://doi.org/10.1007/bf02013116
Abstract
The in vitro activity of RO 23-6240 was compared with that of norfloxacin, ofloxacin and ciprofloxacin as well as four other antimicrobial agents against 345 recent clinical isolates. The MICs of RO 23-6240 againstEnterobacteriaceae andAcinetobacter anitratum was ⩽0.5mg/l. At the same concentration of the compound 90% of staphylococci were inhibited. AgainstEnterococcm faecalis andPseudomonas aeruginosa RO 23-6240 proved less active, having MIC90 values of 4.0 mg/l and 8.0 mg/l, respectively.Enterobacteriaceae and staphylococci strains that were resistant to piperacillin, cefotaxime or tobramycin were susceptible to the compound. In general the activity of RO 23-6240 was comparable to those of norfloxacin and ofloxacin, but less than that of ciprofloxacin.Keywords
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