Reproductive Survival and Hypoxic Protection as a Function of Radiation Ionization Density: Further Studies with Murine Leukemia Cells Irradiated in Vitro with Monoenergetic Accelerated Charged Particles and Assayed in Vivo

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Abstract
Mouse lymphocytic leukemia P-388 cells were irradiated in vitro under aerobic or hypoxic conditions with monoenergetic track segments of beams of accelerated He or B ions, and survival of their reproductive capacity was assessed in vivo. These cells showed a maximum cell killing per rad at a relatively low ionization density (ca. 60-80 keV/.mu.m) and their response ceased to depend on the presence or absence of O2 at all LET [linear energy transfer] values above ca. 100 keV/.mu.m. This is similar to the LET dependence of cell killing reported recently for human lymphocytes which die a nonreproductive interphase death, and differes from the response of human kidney derived cells which were studied in vitro by other workers. The significance of these differences in predicting the response of cells and tissues to radiation such as fast neutrons or pi- mesons which produce wide spectra of ionization densities is discussed briefly.

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