Adrenergic regulation of ureogenesis in hepatocytes from adrenalectomized rats

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Abstract
In hepatocytes from control rats, the ureogenic action of epinephrine is mainly mediated through α1‐adrenoceptors and the effect is independent of the presence of extracellular calcium. In hepatocytes from adrenalectomized rats, both α1‐ and β‐adrenoceptors are involved in the action of epinephrine. Furthermore, the α1‐adrenergic‐mediated stimulation of ureogenesis in these cells is dependent on the presence of extracellular calcium. Our results indicate that glucocorticoids modulate the calcium dependency of α1‐adrenergic effects and are consistent with our suggestion that two pathways are involved in the transduction of the α1‐adrenergic signal.